Endocrine Abstracts

Introduction: Graves’ disease is a common autoimmune disease that can be complicated by orbital damage sometimes threatening the visual prognosis. We report the case of a patient with Graves’ orbitopathy and we discuss the difficulties of clinical evaluation and therapeutic management.Case report: A 68-year-old woman presented to our department complaining of eye protrusion and progressive vision reduction in both eyes. She has had a history of...

Introduction: Besides insulin allergy, several other forms of insulin intolerance are possible. Adipose panniculitis (AP) is an acute form.Purpose: Describe the clinical, paraclinical and evolution of AP.Clinical case: 64-year-old patient, type 2 diabetic for 24 years on premixed human insulin for 10 years. He consults for itchy erythematous lesions at the insulin injection sites. The lesion begins with an immediate pruritus then a...

Introduction: Mitochondrial neuro-gastro-intestinal encephalopathy (MNGIE) is a rare autosomal recessive disease caused by a mutation in the TYMP gene.Patients-methods: Retrospective study including 2 cases (brother and sister) followed for MNGIE confirmed by genetic study at the endocrinology department of Sfax.Results: -> 1st case: 25-year-old man, follow-up for diabetes, dilated cardiomyopathy, renal lithiasis, MNGIE.<p ...

Autoimmune thyroid disease (AITD), including Graves’ disease (GD) and Hashimoto’s thyroiditis (HT), is caused by multiple genetic and environmental factors. The clinical and immunological features of GD and HT are distinct; however, there are multiplex families with both GD and HT. In order to study the genetic susceptibility factors to AITDs, we have followed up 115 control members belonging to a large Tunisian family with a high prevalence of AITDs (Akr family) dur...

The metabolic syndrome (MetS) is a constellation of physiological and biochemical abnormalities characterized by obesity, hyperglycaemia, elevated triglycerides and decreases in high density lipoprotein cholesterol (HDL-C), and hypertension. The MetS promotes atherosclerosis, and increases the risk of developing diabetes and cardiovascular disease (CVD), as well as rates of mortality. Thus, it has become one of the major public health challenges worldwide. In Tunisia, few stud...

Introduction: Hyperthyroidism (HT) has been associated with hepatic dysfunction in the presence or absence of congestive heart failure (CHF). Our objective is to study the correlation between the clinical and biological presentation of hepatic abnormalities and the cardiac status.Patients and methods: This retrospective study included 17 patients hospitalized in the endocrinology department of Hedi Chaker Hospital in Sfax over 20 years (1997–2017). ...

Introduction: Adrenal cystic lesions are uncommon and mostly identified incidentally during radiological investigations or at surgery for unrelated reasons. Its incidence varies between 0.064 and 0.18%. Adrenal cysts are classified as endothelial cysts, pseudocysts, epithelial cysts, and parasitic cysts.Case report: A 45-year-old female with a past medical history of systemic hypertensive disease for 2 years, presented with recurrent abdominal pain durin...

IntroductionType 3 autoimmune polyendocrine syndrome (APS-3) is defined by the presence of an autoimmune thyroid disease and another autoimmune illness, excluding Addison’s disease; this is a frequent combination. Graves’ disease (GD) is an autoimmune disorder affecting approximately 0.5% of general population. It’s occurrence in autoimmune polyendocrine syndrome (APS) is less common than Hashimoto thyroiditis. The aim of our study was to ...

IntroductionAutoimmune Polyendocrine Syndrome (APS) is defined by the presence of 2 or more autoimmune induced endocrine failures in a single patient. There are 4 types of APS: type1 including chronic muco-cutaneous candidiasis, hypoparathyroidism, Addison disease (AD) and ectodermal dystrophy, APS type 2 and 3 containing autoimmune thyroide disease (AITD), type1 diabetes (DT1) with (type2) or without adrenal failure (type3) and type 4 not falling into t...

IntroductionVasculitis with antineutrophilic cytoplasmic antibodies (ANCA) has been reported in patients treated with anti-thyroid drugs, especially Propylthiouracil and exceptionally with benzylthiouracil (BTU). We present here a case of ANCA-anti-MPO-associated vasculitis related to BTU.Case presentationA 46 old women was treated with BTU during 18 months for Basedow’s...